Organic letters

Orthosilicate-mediated esterification of monosubstituted phosphinic acids

YR Dumond, RL Baker, JL Montchamp

Index: Dumond, Yves R.; Baker, Rhonda L.; Montchamp, Jean-Luc Organic Letters, 2000 , vol. 2, # 21 p. 3341 - 3344

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Citation Number: 45

Abstract

Monosubstituted phosphinic acids are esterified with orthosilicates in excellent yields. Phosphinylidene-containing acids react selectively under these conditions, while disubstituted phosphinic acids and phosphonic acids remain unchanged. One-pot procedures are also described for the preparation of phosphinate esters from an alcohol. This novel method provides a convenient and general alternative to more commonly ...