Hydrogen-atom abstraction/cyclization in synthesis. Direct syntheses of coumestan and coumestrol
GA Kraus, N Zhang
Index: Kraus, George A.; Zhang, Ning Journal of Organic Chemistry, 2000 , vol. 65, # 18 p. 5644 - 5646
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Citation Number: 47
Abstract
Coumestrol (1) is a phytoestrogen which is found in plants. 1 Although it is one of the most potent phytoestrogens, its estrogenic activity is approximately 77 times less potent than estradiol, the primary human estrogen and the standard by which activity is measured. 2 Coumestrol is present in alfalfa, cabbage, and, to a lesser extent, soybeans. It is the subject of recent concern in animal reproductive physiology because it lowers the amount of natural estrogen in animals. 3 A ...
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