Total syntheses of three natural products, vignafuran, 2-(4-hydroxy-2-methoxyphenyl)-6-methoxybenzofuran-3-carboxylic acid methyl ester, and coumestrol from a …

…, N Suzuki, A Yasuhara, Y Egawa, A Kasano…

Index: Hiroya, Kou; Suzuki, Naoyuki; Yasuhara, Akito; Egawa, Yuya; Kasano, Atsushi; Sakamoto, Takao Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 24 p. 4339 - 4346

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Citation Number: 74

Abstract

Between 1966 and 1969, Castro et al. 6a,b reported pioneering work involving the copper(I) halide-catalyzed sequential coupling and cyclization reactions of 2-iodophenol and 2-iodoaniline with Cu-acetylide derivatives to give benzo[b]furans and indoles, respectively (Scheme 1). In spite of its usefulness, Castro's method has not seen wide use, because explosive Cu-acetylides have to be prepared and isolated. Subsequently, Owen 6c and Nilsson 6d independently ...