An enantiopure cyclophane-type imidazole with no central but planar chirality

Y Ishida, E Iwasa, Y Matsuoka, H Miyauchi…

Index: Ishida, Yasuhiro; Iwasa, Eriko; Matsuoka, Yuki; Miyauchi, Hiroyuki; Saigo, Kazuhiko Chemical Communications, 2009 , # 23 p. 3401 - 3403

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Citation Number: 5

Abstract

For the design of imidazole-based chiral organocatalysts, the most widely adopted approach is to introduce chiral substituent(s) to an imidazole core. However, such a strategy in design usually leads to imidazoles with complicated structure and/or chemically labile bond(s) (A–E). An alternative approach is to create imidazoles with 'topological chirality', such as axial, helical or planar chirality. In these cases, a well-defined dissymmetric structure may be constructed by ...