Catalytic racemisation of chiral amines and application in dynamic kinetic resolution

AJ Blacker, MJ Stirling, MI Page

Index: Blacker, A. John; Stirling, Matthew J.; Page, Michael I. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 642 - 648

Full Text: HTML

Citation Number: 81

Abstract

A mild and efficient procedure for the racemisation of optically active amines has been developed and applied to the dynamic kinetic resolution (DKR) of a racemic amine. Pentamethylcyclopentadienyliridium (III) iodide dimer dissolved in a convenient solvent is the precatalyst that reacts in situ with primary, secondary, or tertiary amines to form what we have named a SCRAM catalyst. This is able to dehydrogenate a substrate amine to form ...

Related Articles:

Reductive Amination of Aldehydes and Amines with an Efficient Pd/NiO Catalyst

[Yang, Huimin; Cui, Xinjiang; Deng, Youquan; Shi, Feng Synthetic Communications, 2014 , vol. 44, # 9 p. 1314 - 1322]

Reductive amination of aromatic aldehydes and ketones with nickel boride

[Saxena, Ira; Borah, Ruli; Sarma, Jadab C. Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 4 p. 503 - 504]

Development of a General Non??Noble Metal Catalyst for the Benign Amination of Alcohols with Amines and Ammonia

[Cui, Xinjiang; Dai, Xingchao; Deng, Youquan; Shi, Feng Chemistry - A European Journal, 2013 , vol. 19, # 11 p. 3665 - 3675]

Reduction of imines with zinc borohydride supported on silica gel. Highly stereoselective synthesis of substituted cyclohexylamines

[Ranu, Brindaban C.; Sarkar, Arunkanti; Majee, Adinath Journal of Organic Chemistry, 1997 , vol. 62, # 6 p. 1841 - 1842]

Cp∗ Ir-catalyzed N-alkylation of amines with alcohols. A versatile and atom economical method for the synthesis of amines

[Fujita, Ken-ichi; Enoki, Youichiro; Yamaguchi, Ryohei Tetrahedron, 2008 , vol. 64, # 8 p. 1943 - 1954]

More Articles...