Squaramides as potent transmembrane anion transporters

N Busschaert, IL Kirby, S Young…

Index: Busschaert, Nathalie; Kirby, Isabelle L.; Young, Sarah; Coles, Simon J.; Horton, Peter N.; Light, Mark E.; Gale, Philip A. Angewandte Chemie - International Edition, 2012 , vol. 51, # 18 p. 4426 - 4430

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Citation Number: 87

Abstract

The transmembrane transport of anions, particularly chloride and bicarbonate, is an important biological process that is normally regulated by transmembrane ion channels. A range of diseases, known as “channelopathies”,[1] of which cystic fibrosis is the most common example, are caused by malfunctioning ion channels.[2] There has therefore been significant interest recently in the development of small, druglike molecules that can ...