Autocatalytic hydrolysis of V-type nerve agents

…, WT Beaudry, DK Rohrbaugh, LR Procell…

Index: Yang, Yu-Chu; Szafraniec, Linda L.; Beaudry, William T.; Rohrbaugh, Dennis K.; Procell, Lawrence R.; Samuel, John B. Journal of Organic Chemistry, 1996 , vol. 61, # 24 p. 8407 - 8413

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Citation Number: 109

Abstract

Both V-type nerve agents MeP (O)(OR)(SCH2CH2NR'2), VX (R= C2H5; R'= i-C3H7) and its isomeric analog RVX (the “Russian V-agent”, R= i-C4H9; R'= C2H5), react slowly but completely with an equimolar amount of H2O via exclusive PS cleavage to produce the corresponding phosphonic acid (MeP (O)(OR) OH) and 2-aminoethanethiol (HSCH2CH2NR'2). The reaction is believed to be initiated by nucleophilic attack of the ...