Synthesis and biological evaluation of novel isopropanolamine derivatives as non-peptide human immunodeficiency virus protease inhibitors

L Zhou, Q Yang, Y Wang, Y Hu, X Luo, D Bai…

Index: Zhou, Lijun; Yang, Qingang; Wang, Yong; Hu, Youhong; Luo, Xiaomin; Bai, Donglu; Li, Shukun Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 8 p. 1147 - 1152

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Citation Number: 3

Abstract

Novel potential human immunodeficiency virus (HIV) protease inhibitors were designed by a combination of nelfinavir and amprenavir motifs. The designed compounds were prepared by a facile synthetic route and their stereochemistry was further confirmed by a stereospecific synthesis from commercially available (S)-2-oxiranylmethyl m- nitrobenzenesulfonate. All compounds were tested for their ability in inhibiting HIV type 1 ...