Synthesis and antibacterial activity of 4, 4′-(aryl or alkyl methylene)-bis (1H-pyrazol-5-ol) derivatives

S Bhavanarushi, V Kanakaiah, G Bharath…

Index: Bhavanarushi; Kanakaiah; Bharath, Gandu; Gangagnirao; Vatsala Rani Medicinal Chemistry Research, 2014 , vol. 23, # 1 p. 158 - 167

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Citation Number: 11

Abstract

Abstract A rapid, improved, and environmentally benign synthesis of 4, 4′-aryl or alkyl methylene-bis (1 H-pyrazol-5-ols) has been accomplished by tandem Knoevenagel– Michael reaction of 1-aryl-3-alkyl-1 H-pyrazol-5-ol with various aldehydes catalyzed by ammonium acetate. All the synthesized compounds 3a–v were evaluated in vitro for their antibacterial activity against Pseudomonas aeruginosa, Xanthomonas protophormiae, ...

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