Tandem Knoevenagel–Michael Reaction of 1-Phenyl-3-methyl-5-pyrazolone with Aldehydes Using 3-Aminopropylated Silica Gel as an Efficient and Reusable …

S Sobhani, AR Hasaninejad, MF Maleki…

Index: Sobhani, Sara; Hasaninejad, Ali-Reza; Maleki, Mahdi Faal; Parizi, Zahra Pakdin Synthetic Communications, 2012 , vol. 42, # 15 p. 2245 - 2255

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Citation Number: 26

Abstract

Pyrazoles are an important class of bioactive drug targets in the pharmaceutical industry. They are the core structure of numerous biologically active compounds. [ 1 1. McDonald , E. ; Jones , K. ; Brough , PA ; Drysdale , MJ ; Workman , P. Discovery and development of pyrazole-scaffold Hsp90 inhibitors . Curr. Top. Med. Chem. 2006 , 6 , 1193 – 1203 . [CrossRef], [PubMed], [Web of Science ®] View all references ] For example, they exhibit anti-anxiety, antipyretic, ...