Total synthesis and biological evaluation of viscolin, a 1, 3-diphenylpropane as a novel potent anti-inflammatory agent

…, PC Kuo, YL Leu, AG Damu, YH Wang, TS Wu

Index: Su, Chung-Ren; Shen, Yuh-Chiang; Kuo, Ping-Chung; Leu, Yann-Lii; Damu, Amooru G.; Wang, Yea-Hwey; Wu, Tian-Shung Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6155 - 6160

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Citation Number: 26

Abstract

Total synthesis of viscolin, an anti-inflammatory 1, 3-diphenylpropane isolated from Viscum coloratum, employing the Wittig reaction is reported. Key steps in the synthesis of viscolin depend on the selection of protecting groups to maintain the para hydroxyl group that is the most critical chemical structure influencing the biological activity of viscolin and the utilization of microwave-assisted Wittig olefination reaction. Anti-inflammatory potency of ...

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines …

[Huang, Guan-Jhong; Bhaskar Reddy, M. Vijaya; Kuo, Ping-Chung; Huang, Chieh-Hung; Shih, Hung-Cheng; Lee, E.-Jian; Yang, Mei-Lin; Leu, Yann-Lii; Wu, Tian-Shung European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 371 - 378]

An Efficient Synthesis of a Potent Anti-inflammatory Agent, Viscolin, and Its Inducible Nitric Oxide Synthase Inhibitory Activity

[Kuo, Ping-Chung; Chen, Yi-Hsien; Leu, Yann-Lii; Huang, Chieh-Hung; Liao, Yu-Ren; Lee, E.-Jian; Yang, Mei-Lin; Wu, Tian-Shung Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 4 p. 557 - 561]

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines …

Total synthesis and biological evaluation of viscolin, a 1, 3-diphenylpropane as a novel potent anti-inflammatory agent

Abstract

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