A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines …

GJ Huang, MVB Reddy, PC Kuo, CH Huang…

Index: Huang, Guan-Jhong; Bhaskar Reddy, M. Vijaya; Kuo, Ping-Chung; Huang, Chieh-Hung; Shih, Hung-Cheng; Lee, E.-Jian; Yang, Mei-Lin; Leu, Yann-Lii; Wu, Tian-Shung European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 371 - 378

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Citation Number: 11

Abstract

In the present report, a concise synthesis of viscolin (1) has been achieved. The anti- inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. ...