An Environmentally Benign Multicomponent Synthesis of Some Novel 2??Methylthio Pyrimidine Derivatives Using MCM??41??NH2 as Nanoreactor and Nanocatalyst

S Rostamizadeh, M Nojavan

Index: Rostamizadeh, Shahnaz; Nojavan, Masoomeh Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 2 p. 418 - 422

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Citation Number: 6

Abstract

Abstract Some novel 4-amino-6-aryl-2-methylthio pyrimidine-5-carbonitrile derivatives were synthesized through a one-pot three-component reaction of an aldehyde, malononitrile, and S-methylisothiouronium iodide, using MCM-41-NH 2 as nanoreactor and nanocatalyst. This protocol has some advantages including application of readily available and nonhazardous materials, benign reaction conditions (ambient temperature, solvent-free, and one-pot ...