Facile One??Pot Synthesis of Oxazolidin??2??ones from Phenyl 2??Hydroxyalkyl Selenides

SR Sheng, HR Luo, ZZ Huang, WK Sun…

Index: Sheng, Shou-Ri; Luo, Hai-Rong; Huang, Zhen-Zhong; Sun, Wu-Kang; Liu, Xiao-Ling Synthetic Communications, 2007 , vol. 37, # 16 p. 2693 - 2699

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Citation Number: 4

Abstract

Abstract A novel, convenient, efficient, three??step, one??pot synthesis of 2??oxazolidinones from phenyl 2??hydroxyalkyl selenides was developed. Using this methodology, 2?? oxazolidinones are obtained in good yields (76–85%) by reaction of phenyl 2??hydroxyalkyl selenides with benzoyl isocyanate and subsequent oxidation/cyclization, followed by hydrolysis with hydrochloric acid solution.