Synthesis and Characterization of the Biologically Active 2??[1??(4??Chlorobenzyl)??1H??indol??3??yl]??2??oxo??N??pyridin??4??yl Acetamide

M Knaack, P Emig, JW Bats, M Kiesel…

Index: Knaack, Martin; Emig, Peter; Bats, Jan W.; Kiesel, Michael; Mueller, Arndt; Guenther, Eckhard European Journal of Organic Chemistry, 2001 , # 20 p. 3843 - 3847

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Citation Number: 16

Abstract

Abstract The spectroscopic characterization of the new potent tubulin inhibitor 2-[1-(4- chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-yl acetamide (D-24851)(7), which is under preclinical development, is described. The synthesis was optimized and follows a straightforward route from the unsubstituted indole via the 1-(4-chlorobenzyl)-indole (3) and the indol-3-yl-2-oxo-acetyl chloride (5) to the indol-3-yl-2-oxo acetamide product. The ...