Tetrahedron

Tetramethylethylene diamine/trimethylsilyl chloride mediated addition of benzyl copper reagents to α, β-unsaturated esters

PS van Heerden, BCB Bezuidenhoudt, D Ferreira

Index: Van Heerden, Pieter S.; Bezuidenhoudt, Barend C. B.; Ferreira, Daneel Tetrahedron, 1996 , vol. 52, # 37 p. 12313 - 12322

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Citation Number: 21

Abstract

Several benzylic copper reagents, benzylcopper, 4-methoxybenzylcopper and 1- phenylethylcopper, facilitate the conjugate addition of the corresponding benzyl ligands to α, β-enoates in the presence of tetramethylethylene diamine and trimethylsilyl chloride in high yields.