Total synthesis of verrucarol

BM Trost, PG McDougal

Index: Trost; McDougal Journal of the American Chemical Society, 1982 , vol. 104, # 22 p. 6110 - 6112

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Citation Number: 45

Abstract

The trichothecanes are a group of sesquiterpenoid mycotoxins that exhibit a wide array of biological activity, including significant cytotoxicity.'The more potent of this class are the macrocyclic di-and trilactones of verrucarol (2) such as the roridins, baccharins, and verrucarins. Because of our interest in the synthesis of verrucarin A (1),* as well as our desire to showcase an alter-