Developing new isotope-coded mass spectrometry-cleavable cross-linkers for elucidating protein structures

…, W Kandur, A Kao, S Rychnovsky, L Huang

Index: Yu, Clinton; Kandur, Wynne; Kao, Athit; Rychnovsky, Scott; Huang, Lan Analytical Chemistry, 2014 , vol. 86, # 4 p. 2099 - 2106

Full Text: HTML

Citation Number: 9

Abstract

Structural characterization of protein complexes is essential for the understanding of their function and regulation. However, it remains challenging due to limitations in existing tools. With recent technological improvements, cross-linking mass spectrometry (XL-MS) has become a powerful strategy to define protein–protein interactions and elucidate structural topologies of protein complexes. To further advance XL-MS studies, we present here the ...