N-(benzyloxycarbonyl) glycine esters and amides as new anticonvulsants
M Geurts, JH Poupaert, GKE Scriba…
Index: Geurts, Muriel; Poupaert, Jacques H.; Scriba, Gerhard K. E.; Lambert, Didier M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 1 p. 24 - 30
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Citation Number: 43
Abstract
Glycine is a small neutral amino acid exhibiting weak anticonvulsant activities in vivo. Recently, studies have demonstrated that N-(benzyloxycarbonyl) glycine (1) antagonized seizures superior to glycine in addition to activity in the maximal electroshock (MES) test, a convulsive model where glycine is inactive. In the present study a series of ester and amide derivatives of 1 as well as esters of N-(3-phenylpropanoyl) glycine (5) have been ...
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