Catalyst and solvent-free amidation of inactive esters of N-protected amino acids
KC Nadimpally, K Thalluri, NB Palakurthy, A Saha…
Index: Nadimpally, Krishna Chaitanya; Thalluri, Kishore; Palakurthy, Nani Babu; Saha, Abhijit; Mandal, Bhubaneswar Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2579 - 2582
Full Text: HTML
Citation Number: 16
Abstract
Abstract A catalyst free procedure for the preparation of amides from inactive esters of N- protected amino acids and various amines is demonstrated under mild reaction conditions. Our effort to recover excess amine and generated alcohol is an approach towards environment friendly and cost effective synthesis under easy operational conditions.
Related Articles:
[Thalluri, Kishore; Nadimpally, Krishna Chaitanya; Chakravarty, Maharishi Parasar; Paul, Ashim; Mandal, Bhubaneswar Advanced Synthesis and Catalysis, 2013 , vol. 355, # 2-3 p. 448 - 462]
A food effect study of an oral thrombin inhibitor and prodrug approach to mitigate it
[Dosa, Stefan; Stirnberg, Marit; Luelsdorff, Verena; Haeussler, Daniela; Maurer, Eva; Guetschow, Michael Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6489 - 6505,17]
Preparation of Carboxamides via Carboxylic-Phosphoric Anhydrides
[Gaede, Bruce Organic Process Research and Development, 1999 , vol. 3, # 2 p. 92 - 93]
N-(benzyloxycarbonyl) glycine esters and amides as new anticonvulsants
[Geurts, Muriel; Poupaert, Jacques H.; Scriba, Gerhard K. E.; Lambert, Didier M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 1 p. 24 - 30]
Peptide Synthesis via Oxidation of N-Acetyl-α-amino Acid Phenylhydrazides1
[Milne,H.B.; Kilday,W. Journal of Organic Chemistry, 1965 , vol. 30, p. 64 - 66]