Potent targeting of the STAT3 protein in brain cancer stem cells: a promising route for treating glioblastoma

S Haftchenary, HA Luchman, AO Jouk…

Index: Haftchenary, Sina; Luchman, H. Artee; Jouk, Andriana O.; Veloso, Anthony J.; Page, Brent D. G.; Cheng, Xin Ran; Dawson, Sean S.; Grinshtein, Natalie; Shahani, Vijay M.; Kerman, Kagan; Kaplan, David R.; Griffin, Carly; Aman, Ahmed M.; Al-Awar, Rima; Weiss, Samuel; Gunning, Patrick T. ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 11 p. 1102 - 1107

Full Text: HTML

Citation Number: 33

Abstract

The STAT3 gene is abnormally active in glioblastoma (GBM) and is a critically important mediator of tumor growth and therapeutic resistance in GBM. Thus, for poorly treated brain cancers such as gliomas, astrocytomas, and glioblastomas, which harbor constitutively activated STAT3, a STAT3-targeting therapeutic will be of significant importance. Herein, we report a most potent, small molecule, nonphosphorylated STAT3 inhibitor, 31 (SH-4-54) ...