Chemistry Letters

An efficient one-step reductive N-monoalkylation of α-amino acids

…, N Kurokawa, N Higuchi, M Saito, M Hashimoto…

Index: Ohfune, Yasufumi; Kurokawa, Natsuko; Higuchi, Naoki; Saito, Masayuki; Hashimoto, Masaki; et al. Chemistry Letters, 1984 , p. 441 - 444

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Citation Number: 53

Abstract

Reactions of protection-free a-amino acids with aldehydes or ketones in the presence of sodium cyanoborohydride afforded the N-monoalkylated amino acids in inorganic salt-free form. Application of this method to the synthesis of N-alkyl derivatives of biologically important amino acids is also described.

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