The first highly enantioselective homogeneously catalyzed asymmetric reductive amination: synthesis of α-n-benzylamino acids
R Kadyrov, TH Riermeier, U Dingerdissen…
Index: Kadyrov, Renat; Riermeier, Thomas H.; Dingerdissen, Uwe; Tararov, Vitali; Boerner, Armin Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 4067 - 4070
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Citation Number: 105
Abstract
High-throughput screening considering a library of 96 chiral P-ligands involved in two types of RhI complexes was used for the identification of homogeneous catalysts for the highly enantioselective reductive amination of α-keto acids with benzylamine. After optimization of the reaction conditions and scale-up with a cationic Rh-Deguphos catalyst, a range of chiral α-amino acids could be produced by this new reaction in good yield and by up to 98% ee.
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