Three??Component (Domino) Reaction Affording Substituted Pyrroloquinazolines: Cyclization Regioselectivity and Stereoselectivity
O Paleta, B Dolenský, J Paleček…
Index: Paleta, Oldrich; Dolensky, Bohumil; Palecek, Jiri; Kvicala, Jaroslav European Journal of Organic Chemistry, 2013 , # 7 p. 1262 - 1270
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Abstract
Abstract The cyclization involving 2-(aminomethyl) aniline, methyl 3, 3, 3-trifluoropyruvate, and various oxo compound afforded linearly annulated pyrroloquinazolines, for example,(2R*, 3aS*)-2-hydroxy-3a-phenyl-2-trifluoromethyl-3, 3a, 4, 9-tetrahydropyrrolo [2, 1-b] quinazolin-1 (2H)-one (cis-8), as the major product, possessing the skeleton of the alkaloids of the vasicine group, along with angularly annulated products, for example,(2S* ...
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