4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors
…, AS Vellekoop, AM Klos, PJ Crocker, C Hassler…
Index: Pechulis, Anthony D.; Beck, James P.; Curry, Matt A.; Wolf, Mark A.; Harms, Arthur E.; Xi, Ning; Opalka, Chet; Sweet, Mark P.; Yang, Zhicai; Vellekoop, A. Samuel; Klos, Andrew M.; Crocker, Peter J.; Hassler, Carla; Laws, Mia; Kitchen, Douglas B.; Smith, Mark A.; Olson, Richard E.; Liu, Shuang; Molino, Bruce F. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7219 - 7222
Full Text: HTML
Citation Number: 7
Abstract
Novel 4-phenyl tetrahydroisoquinolines that inhibit both dopamine and norepinephrine transporters were designed and prepared. In this Letter, we describe the synthesis, in vitro activity and associated structure–activity relationships of this series. We also report the ex vivo NET occupancy of a representative compound, 41.
Related Articles:
Experimental and computational studies on the mechanism of N-heterocycle CH activation by Rh (I)
[Wiedemann, Sean H.; Lewis, Jared C.; Ellman, Jonathan A.; Bergman, Robert G. Journal of the American Chemical Society, 2006 , vol. 128, # 7 p. 2452 - 2462]
[Paleta, Oldrich; Dolensky, Bohumil; Palecek, Jiri; Kvicala, Jaroslav European Journal of Organic Chemistry, 2013 , # 7 p. 1262 - 1270]
[Andrews, Ian P.; Atkins, Richard J.; Breen, Gary F.; Carey, John S.; Forth, Michael A.; Morgan, David O.; Shamji, Amin; Share, Andrew C.; Smith, Stephen A. C.; Walsgrove, Timothy C.; Wells, Andrew S. Organic Process Research and Development, 2003 , vol. 7, # 5 p. 655 - 662]
[Andrews, Ian P.; Atkins, Richard J.; Breen, Gary F.; Carey, John S.; Forth, Michael A.; Morgan, David O.; Shamji, Amin; Share, Andrew C.; Smith, Stephen A. C.; Walsgrove, Timothy C.; Wells, Andrew S. Organic Process Research and Development, 2003 , vol. 7, # 5 p. 655 - 662]
[Andrews, Ian P.; Atkins, Richard J.; Breen, Gary F.; Carey, John S.; Forth, Michael A.; Morgan, David O.; Shamji, Amin; Share, Andrew C.; Smith, Stephen A. C.; Walsgrove, Timothy C.; Wells, Andrew S. Organic Process Research and Development, 2003 , vol. 7, # 5 p. 655 - 662]