CeCl 3· 7H 2 O/IBX-promoted oxidation of 3-alkylindoles to 3-hydroxyoxindoles
JS Yadav, BVS Reddy, CS Reddy, AD Krishna
Index: Yadav; Reddy, B.V. Subba; Reddy, Ch. Suresh; Krishna Tetrahedron Letters, 2007 , vol. 48, # 11 p. 2029 - 2032
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Citation Number: 32
Abstract
3-Alkylindoles undergo smooth oxidation with IBX in the presence of CeCl3· 7H2O in aqueous acetonitrile at ambient temperature to afford the corresponding 3-hydroxyoxindoles in high yields. This method is very useful for the direct preparation of 3-hydroxyoxindoles from 3-alkylindoles. Operational simplicity, mild and neutral reaction conditions in aqueous solution are the key features of this protocol.
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