A reasonably stereospecific multistep conversion of Boc-protected α-amino acids to Phth-protected β 3-amino acids
…, A Capperucci, A Degl'Innocenti, R Terlizzi, M Tiecco
Index: Temperini, Andrea; Capperucci, Antonella; Degl'Innocenti, Alessandro; Terlizzi, Raffaella; Tiecco, Marcello Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4121 - 4124
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Citation Number: 8
Abstract
A method for the synthesis of β3-amino acids starting from α-amino acids is described. This conversion can be effected by an eight-step procedure which involves the transformation of the carboxylic group into an alkyne followed by a selenium-mediated conversion of the carbon–carbon triple bond to a Se-phenyl selenocarboxylate intermediate. The reactive Se- phenyl selenocarboxylate intermediates can be trapped with water, alcohols or the amine ...
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