Efficient synthesis of β-enaminoesters via highly stereoselective Reformatsky reaction with disubstituted formamides as novel electrophiles

YY Ke, YJ Li, JH Jia, WJ Sheng, L Han, JR Gao

Index: Ke, Yi-Yin; Li, Yu-Jin; Jia, Jian-Hong; Sheng, Wei-Jian; Han, Liang; Gao, Jian-Rong Tetrahedron Letters, 2009 , vol. 50, # 13 p. 1389 - 1391

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Citation Number: 18

Abstract

The Reformatsky reaction is one of the fundamental reactions in organic synthesis. 9 and 10 It is well recognized 10, 11, 12 and 13 that the Reformatsky reagents as nucleophiles reacted with a number of electrophiles including aldehydes, ketones, nitriles, amides, and imides affording β-hydroxy or α,β-unsaturated products. However, there have been few studies on disubstituted formamides as electrophiles in the Reformatsky reaction. In this Letter, we report an ...