DNA-catalyzed polymerization
X Li, ZYJ Zhan, R Knipe, DG Lynn
Index: Li, Xiaoyu; Zhan, Zheng-Yun J.; Knipe, Rachel; Lynn, David G. Journal of the American Chemical Society, 2002 , vol. 124, # 5 p. 746 - 747
Full Text: HTML
Citation Number: 148
Abstract
Native DNA oligomers are shown to be stereoselective catalysts for the polymerization of 5'- amino-3'-acetaldehyde-modified thymidine/adenosine nucleosides through reductive amination. The reaction follows step-growth kinetics to read the encoded sequence and chain-length information in the antiparallel direction. Single mismatches in the template are selected against at a level of> 100: 1. A method is therefore established to translate ...
Related Articles:
Synthesis of pyrimidine 3'-allyl-2', 3'-dideoxyribonucleosides by free-radical coupling
[Chu, Chung K.; Doboszewski, B.; Schmidt, Walter; Ullas, Giliyar V. Journal of Organic Chemistry, 1989 , vol. 54, # 11 p. 2767 - 2769]
Polymerization on solid supports
[Li, Xiaoyu; Lynn, David G. Angewandte Chemie - International Edition, 2002 , vol. 41, # 23 p. 4567 - 4569]
Synthesis of analogues of oligonucleotides; synthesis of unprotected C-linked di-and tri-nucleotides
[Mellor, Ben J.; Thomas, Eric J. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 4 p. 747 - 757]
Synthesis of pyrimidine 3'-allyl-2', 3'-dideoxyribonucleosides by free-radical coupling
[Chu, Chung K.; Doboszewski, B.; Schmidt, Walter; Ullas, Giliyar V. Journal of Organic Chemistry, 1989 , vol. 54, # 11 p. 2767 - 2769]