Synthesis of pyrimidine 3'-allyl-2', 3'-dideoxyribonucleosides by free-radical coupling
…, B Doboszewski, W Schmidt, GV Ullas…
Index: Chu, Chung K.; Doboszewski, B.; Schmidt, Walter; Ullas, Giliyar V. Journal of Organic Chemistry, 1989 , vol. 54, # 11 p. 2767 - 2769
Full Text: HTML
Citation Number: 62
Abstract
The crystal structure of 7 was determined to analyze the effect on the molecular conformation of the 3'-substituent. None of the bond lengths and angles are exceptional. The most important feature of the structure is the C3'-endo conformation of the sugar ring (pseudorotational phase angle P= 16.0'). This conformation is commonly observed for other uridine analogues, but not for AZT or 3'-azido-2 ', 3'-dideoxyuridine ((3-87), 18 active anti- ...
Related Articles:
[Li, Xiaoyu; Zhan, Zheng-Yun J.; Knipe, Rachel; Lynn, David G. Journal of the American Chemical Society, 2002 , vol. 124, # 5 p. 746 - 747]
Polymerization on solid supports
[Li, Xiaoyu; Lynn, David G. Angewandte Chemie - International Edition, 2002 , vol. 41, # 23 p. 4567 - 4569]
Synthesis of analogues of oligonucleotides; synthesis of unprotected C-linked di-and tri-nucleotides
[Mellor, Ben J.; Thomas, Eric J. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 4 p. 747 - 757]