Regioselective synthesis of 1-alkyl-5-(indol-3-yl-and-2-yl) pyrrolidin-2-ones from available reagents
…, AE Kovrov, GA Golubeva, LA Sviridova
Index: Sadovoy; Kovrov; Golubeva; Sviridova Chemistry of Heterocyclic Compounds, 2011 , vol. 46, # 10 p. 1215 - 1223
Full Text: HTML
Citation Number: 6
Abstract
The reaction under mild conditions of 1-alkyl-5-hydroxypyrrolidin-2-ones with different indoles having a free 3 position leads exclusively to 1-alkyl-5-(indol-3-yl)pyrrolidin-2-ones but if position 3 is occupied to 1-alkyl-5-(indol-2-yl)pyrrolidin-2-ones. ... Keywords: 1-alkyl-5-hydroxypyrrolidin -2-ones, 1-alkyl-5-indolylpyrrolidin-2-ones, indoles, amido- alkylation. ... It is known that the combination of pharmacophoric fragments in a single molecule often leads to a strengthening and/or ...
Related Articles:
Stereoselective Palladium??Catalyzed Carboaminoxylations of Indoles with Arylboronic Acids and TEMPO
[Kirchberg, Sylvia; Froehlich, Roland; Studer, Armido Angewandte Chemie, International Edition, 2009 , vol. 48, # 23 p. 4235 - 4238]
Palladium-catalyzed direct C-3 arylations of indoles with an air-stable HASPO
[Ackermann, Lutz; Barfuesser, Sebastian Synlett, 2009 , # 5 p. 808 - 812]
[Nagase, Yuta; Shirai, Hiroyuki; Kaneko, Masayoshi; Shirakawa, Eiji; Tsuchimoto, Teruhisa Organic and Biomolecular Chemistry, 2013 , vol. 11, # 9 p. 1456 - 1459]
[Chen, Yongxin; Guo, Shuaibo; Li, Kangning; Qu, Jinpeng; Yuan, Hua; Hua, Qiuru; Chen, Baohua Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 711 - 715]
[Nagase, Yuta; Shirai, Hiroyuki; Kaneko, Masayoshi; Shirakawa, Eiji; Tsuchimoto, Teruhisa Organic and Biomolecular Chemistry, 2013 , vol. 11, # 9 p. 1456 - 1459]