Polyaza cavity-shaped molecules. Annelated derivatives of 2-(2'-pyridyl)-1, 8-naphthyridine and 2, 2'-bi-1, 8-naphthyridine

…, F Lefoulon, D Cantu, R Mahadevan

Index: Thummel, Randolph P.; Lefoulon, Francois; Cantu, David; Mahadevan, Ramanathan Journal of Organic Chemistry, 1984 , vol. 49, # 12 p. 2208 - 2212

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Citation Number: 104

Abstract

A two-step method is presented for the oxidation of the 2-methylene position of 2, 3- cycloalkenopyridines. The pyridyl ketones thus obtained may be reacted with 2- aminonicotinaldehyde to yield 3, 3'-annelated derivatives of 2-(2'-ppidyl)-l, &naphthpidme. Treatment of cyclic a-diketones in a similar manner provided 3, 3'-annelated derivatives of 2, 2'-bi-l, 8naphthyridine. Analyses by NMR indicate that when the 3, 3'bridge contains four ...