Dopamine autoreceptor agonists as potential antipsychotics. 3. 6-Propyl-4, 5, 5a, 6, 7, 8-hexahydrothiazolo [4, 5-f] quinolin-2-amine

BW Caprathe, JC Jaen, LD Wise…

Index: Caprathe, Bradley W.; Jaen, Juan C.; Wise, Lawrence D.; Heffner, Thomas G.; Pugsley, Thomas A.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2736 - 2746

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Citation Number: 41

Abstract

DA autoreceptor agonist from this group of compounds. It inhibited spontaneous locomotor activity (LMA) in rodents, reversed the y-butyrolactone (GBL) induced accumulation of rat striatal DOPA and inhibited brain DA neuronal firing, all suggestive of direct DA autoreceptor agonist activity. However,(+)-6 is not completely free of postsynaptic DA activity, as evidenced by its stimulation of LMA in rats at high doses and its ability to produce ...