Improved process for preparation of tert-butanesulfinyl ketimines of hindered ketones under nitrogen flow

S Tabet, N Rodeville, JG Boiteau…

Index: Han, Zhengxu; Krishnamurthy, Dhileepkumar; Senanayake, Chris H. Organic Process Research and Development, 2006 , vol. 10, # 2 p. 327 - 333

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Abstract

... Organic Process Research & Development. ... An improved process for tert-butanesulfinyl ketimines formation using titanium(IV) alkoxides is described. ... the most hindered example 2j, titanium(IV) isopropoxide was not sufficient to provide complete conversion (12%) in 48 h and 70 ...

New resolution approach for large-scale preparation of enantiopure didesmethylsibutramine (DDMS)

[Han, Zhengxu; Krishnamurthy, Dhileepkumar; Fang, Q. Kevin; Wald, Stephen A.; Senanayake, Chris H. Tetrahedron Asymmetry, 2003 , vol. 14, # 22 p. 3553 - 3556]

First Application of Tunable Alkyl or Aryl Sulfinamides to the Stereoselective Synthesis of a Chiral Amine: Asymmetric Synthesis of (R)-Didesmethylsibutramine ((R)- …

[Han, Zhengxu; Krishnamurthy, Dhileepkumar; Pflum, Derek; Grover, Paul; Wald, Stephen A; Senanayake, Chris H Organic letters, 2002 , vol. 4, # 23 p. 4025 - 4028]