Design, synthesis and biological study of pinacolyl boronate-substituted stilbenes as novel lipogenic inhibitors

BC Das, X Zhao, XY Tang, F Yang

Index: Das, Bhaskar C.; Zhao, Xiaoping; Tang, Xiang-Ying; Yang, Fajun Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5638 - 5641

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Citation Number: 7

Abstract

A pilot library of novel 4, 4, 5, 5-tetramethyl-2-(4-substitutedstyrylphenyl)-1, 3, 2 dioxaborolane derivatives has been synthesized. 4-(4, 4, 5, 5-Tetramethyl-1, 3, 2- dioxaboratophenyl)-methyl triphenylphosphonium bromide 3 was treated with various aldehydes in the presence of 3equiv of tBuONa in DMF, and stirred at room temperature for 4–6h to yield the corresponding boron-containing stilbene derivatives in 71–94% yields. ...