Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake

DE Morrison, F Issa, M Bhadbhade, L Groebler…

Index: Morrison, Daniel E.; Issa, Fatiah; Bhadbhade, Mohan; Groebler, Ludwig; Witting, Paul K.; Kassiou, Michael; Rutledge, Peter J.; Rendina, Louis M. Journal of Biological Inorganic Chemistry, 2010 , vol. 15, # 8 p. 1305 - 1318

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Citation Number: 11

Abstract

Abstract The preparation of boronated triaryl and tetraaryl phosphonium salts of the type [PPh 3 CH 2 R] Br [R is 4-boronophenyl (1), 4-(4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolan-yl) phenyl (2), 3-boronophenyl (3), 3-(4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolan-yl) phenyl (4), 2- boronophenyl (5), 2-(4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolan-yl) phenyl (6), and closo-1, 2- carboran-1-yl (7)] is described. These compounds were prepared by the reaction of ...