9-(1, 3-Dihydroxy-2-propoxymethyl) guanine: a new potent and selective antiherpes agent

…, DF Smee, TR Matthews, JPH Verheyden

Index: Martin; Dvorak; Smee; Matthews; Verheyden Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 759 - 761

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Citation Number: 359

Abstract

The synthesis of a new acyclic analogue of deoxyguanosine, 9-[(1, 3-dihydroxy-2-propoxy) methyl] guanine(DHPG, l), is described starting from epichlorohydrin via condensation of 2-0- (acetoxymethyl)-l, 3-di-O-benzylglycerol (5) with N2, 9-diacetylguanine (6). In vitro studies indicate that DHPG is a potent and broad-acting (herpes simplex virus types 1 and 2, cytomegalovirus, and Epstein-Barr virus) antiherpetic agent. In vivo studies indicate its ...