Enantioselective Synthesis of Both Enantiomers of Cathinone via the Microbiological Reduction of 2-azido-1-phenyl-1-propanone

P Besse, H Veschambre, M Dickman…

Index: Besse; Veschambre; Dickman; Chenevert Journal of Organic Chemistry, 1994 , vol. 59, # 26 p. 8288 - 8291

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Citation Number: 25

Abstract

Cathinone, la, or (-)-(2S)-2-amino-l-phenyl-l-pro-panone is the main active constituent of the products extracted from the fresh leaves of Catha edulis (Khat)'which is found in several countries of East Africa and the Arabian peninsula. The biological activity of cathinone is analogous to that of amphetamines, especially on the cardiovascular system2 and the metabolism of d~ pamine.~ Berrang et al.'have reviewed all the previous studies and ...