Synthesis of optically active N??protected α??aminoketones and α??amino alcohols
ZH Zhou, YL Tang, KY Li, B Liu…
Index: Zhou, Zheng Hong; Tang, Yi Long; Li, Kang Ying; Liu, Bing; Tang, Chu Chi Heteroatom Chemistry, 2003 , vol. 14, # 7 p. 603 - 606
Full Text: HTML
Citation Number: 10
Abstract
Abstract A series of optically active N-protected α-aminoketones were synthesized via the Grignard reaction of the Weinreb amides of the N-tert-butoxycarbonyl amino acids. Reduction of the α-aminoketones by sodium borohydride resulted in the corresponding 1, 2- amino alcohols.© 2003 Wiley Periodicals, Inc. Heteroatom Chem 14: 603–606, 2003; Published online in Wiley InterScience (www. interscience. wiley. com). DOI 10.1002/hc. ...
Related Articles:
[Valverde, Ibai E.; Bauman, Andreas; Kluba, Christiane A.; Vomstein, Sandra; Walter, Martin A.; Mindt, Thomas L. Angewandte Chemie - International Edition, 2013 , vol. 52, # 34 p. 8957 - 8960 Angew. Chem., 2013 , vol. 125, # 34 p. 9126 - 9129,4]
An expedient conversion of α-amino acids into Weinreb amides using COMU® as a coupling agent
[Tyrrell, Elizabeth; Brawn, Peter; Carew, Mark; Greenwood, Iain Tetrahedron Letters, 2011 , vol. 52, # 3 p. 369 - 372]
First synthesis of both enantiomers of the biotin vitamer 8-amino-7-oxopelargonic acid
[Lucet, Denis; Le Gall, Thierry; Mioskowski, Charles; Ploux, Olivier; Marquet, Andree Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 985 - 988]