Preparation of (2, 2-difluoroethenylidene) bis (tributylstannane) and arylation reaction: efficient approach to 1, 1-diaryl-2, 2-difluoroethenes
SY Han, HY Lee, JH Jeon, IH Jeong
Index: Han, Seung Yeon; Lee, Hyo Young; Jeon, Jong Hee; Jeong, In Howa Tetrahedron Letters, 2012 , vol. 53, # 14 p. 1833 - 1836
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Citation Number: 10
Abstract
Reaction of 2, 2-difluoro-1-tributylstannylethenyl p-toluenesulfonate (1) with bis (tributyltin) in the presence of 5mol% Pd (PPh3) 4 and 30equiv LiBr in THF at reflux temperature for 7h afforded (2, 2-difluoroethenylidene) bis (tributylstannane)(2) in a 70% yield. Coupling reaction of 2 with aryl iodides in the presence of 5mol% Pd (PPh3) 4 and 5mol% CuI in DMF at 80° C for 3–4h provided the coupled products 3 in 59–85% yields.
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