Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters

…, F Nannucci, MN Romanelli, S Scapecchi…

Index: Gualtieri; Conti; Dei; Giovannoni; Nannucci; Romanelli; Scapecchi; Teodori; Fanfani; Ghelardini; Giotti; Bartolini Journal of Medicinal Chemistry, 1994 , vol. 37, # 11 p. 1704 - 1711

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Citation Number: 26

Abstract

Previous studies have shown that (R)-(+)-hyoscyamine has analgesic activity as a consequence of increased ACh release following antagonism of central muscarinic autoreceptors. Since the enhancement of central cholinergic transmission could be beneficial for cognitive disorders, we manipulated (E)-(+)-hyoscyamine, synthesizing several derivatives of tropic and 2-phenylpropionic acids, with the aim of obtaining drugs which ...