Escherichia coli O86 O-antigen biosynthetic gene cluster and stepwise enzymatic synthesis of human blood group B antigen tetrasaccharide

…, J Shao, L Zhu, M Li, M Singh, Y Lu, S Lin…

Index: Yi, Wen; Shao, Jun; Zhu, Lizhi; Li, Mei; Singh, Mamata; Lu, Yuquan; Lin, Steven; Li, Hanfen; Ryu, Kang; Shen, Jie; Guo, Hongjie; Yao, Qingjia; Bush, C. Allen; Wang, Peng G. Journal of the American Chemical Society, 2005 , vol. 127, # 7 p. 2040 - 2041

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Citation Number: 67

Abstract

Previous study showed that some Gram-negative bacteria possess human blood group activity. Among them, Escherichia coli O86 has high blood group B activity and weak blood group A activity. This is due to the cell surface O-antigen structure, which resembles that of human blood group B antigen. In this study, we sequenced the entire E. coli O86 antigen gene cluster and identified all the genes responsible for O-antigen biosynthesis by ...