Facile One??Step Syntheses of Modified O??Glycoprotein Galβ1??3GalNAc Structures by Transglycosylation Employing Three β??Galactosidases from Bovine Testes, …

L Kröger, J Thiem

Index: Kroeger, Lars; Thiem, Joachim Journal of Carbohydrate Chemistry, 2005 , vol. 24, # 7 p. 717 - 722

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Citation Number: 6

Abstract

Natural O??glycoproteins such as the Thomsen??Friedenreich antigen or gangliosides contain the motif Galβ1??3GalNAc as an important disaccharide with significant biologic activity. The arrangement of spatial functionalities in this structure are of particular interest with regard to the development of potential leads en route to pharmaceuticals. Therefore, it was desired to obtain access to a range of modified derivatives of the aforementioned motif paying ...