Asymmetric transfer hydrogenation in aqueous media catalyzed by resin-supported peptide having a polyleucine tether
K Akagawa, H Akabane, S Sakamoto, K Kudo
Index: Akagawa, Kengo; Akabane, Hajime; Sakamoto, Seiji; Kudo, Kazuaki Tetrahedron Asymmetry, 2009 , vol. 20, # 4 p. 461 - 466
Full Text: HTML
Citation Number: 29
Abstract
A resin-supported N-terminal prolyl peptide having a β-turn motif and a polyleucine tether has been developed for the organocatalytic asymmetric transfer hydrogenation under aqueous conditions. Polyleucine accelerated the reaction in a highly enantioselective manner by providing a hydrophobic microenvironment around the prolyl residue. The investigation of catalyst structures indicates that the l-form of polyleucine is essential for ...
Related Articles:
[Dawson, Glenn W.; Pickett, John A.; Smiley, Diane W. M. Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 3 p. 351 - 361]
Direct organocatalytic asymmetric reductive Mannich-type reactions
[Tetrahedron Letters, , vol. 47, # 42 p. 7417 - 7421]
Conjugate Reduction of α, β-Unsaturated Aldehydes with Rhodium (bisoxazolinylphenyl) Catalysts
[Kanazawa, Yoshinori; Nishiyama, Hisao Synlett, 2006 , # 19 p. 3343 - 3345]
[Chapuis, Christian; Barthe, Michel; Laumer, Jean-Yves de Saint Helvetica Chimica Acta, 2001 , vol. 84, # 1 p. 230 - 242]
[Li, Jia-Qi; Peters, Byron; Andersson, Pher G. Chemistry - A European Journal, 2011 , vol. 17, # 40 p. 11143 - 11145]