An efficient large??scale synthesis of 1H??indazole??[3??14C] carboxylic acid
RV Coelho, K Schildknegt
Index: Coelho Jr., Richard V.; Schildknegt, Klaas Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 7 p. 675 - 678
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Abstract
Abstract An efficient large-scale carbon-14 synthesis of 1H-indazole-[3-14 C] carboxylic acid starting from [14 C] potassium cyanide is reported. Key transformations encountered during the synthesis include aromatic nucleophilic substitution of 2-nitrofluorobenzene by ethyl [14 C] cyanoacetate, a mild decarbethoxylation and an aniline nitrosation/cyclization. Copyright© 2007 John Wiley & Sons, Ltd.
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