Inactivation of monoamine oxidase B by benzyl 1-(aminomethyl) cyclopropane-1-carboxylate

RB Silverman, X Lu, GD Blomquist, CZ Ding…

Index: Silverman, Richard B.; Lu, Xingliang; Blomquist, Geri D.; Ding, Charles Z.; Yang, Shengtian Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 2 p. 297 - 304

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Citation Number: 12

Abstract

Monoamine oxidase (MAO) is a flavoenzyme that catalyzes the oxidation of various biogenic and xenobiotic amines. Benzyl 1-(aminomethyl) cyclopropane-1-carboxylate (1) was designed as a diactivated cyclopropane mechanism-based inactivator of MAO (Silverman, RB; Ding, CZ; Borrillo, JL; Chang, JTJ Am. Chem. Soc. 1993, 115, 2982).[1, 1-2H2]-1 exhibits a deuterium isotope effect of 4.5 on inactivation, but in D2O the isotope effect is ...