Discovery of bioluminogenic probes for aminopeptidase N imaging

J Li, L Chen, W Wu, W Zhang, Z Ma, Y Cheng…

Index: Chen, Laizhong; Sun, Wei; Li, Jing; Liu, Zhenzhen; Ma, Zhao; Zhang, Wei; Du, Lupei; Xu, Wenfang; Fang, Hao; Li, Minyong Organic and Biomolecular Chemistry, 2013 , vol. 11, # 2 p. 378 - 382

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Citation Number: 13

Abstract

To find an approach that can image the hydrolysis activity of aminopeptidase N (APN) both in vitro and in vivo, three bioluminescent probes have been well designed and synthesized herein. All of them can be recognized and hydrolyzed by APN to produce bioluminescence