An Efficient Synthesis of the Enantiomers of Methadone??D10

BM Gérardy, J Poupaert…

Index: Gerardy, B. M.; Poupaert, J.; Dumont, P. Bulletin des Societes Chimiques Belges, 1981 , vol. 90, # 9 p. 977 - 980

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Abstract

Abstract A reactions sequence is described to prepare the enantiomers of Methadone-d 10. The proposed scheme allows to synthesize racemic Methadone-d 10 with 14% overall yield, starting from benzene-d 6.(-)-Methadone-d 10 hydrochloride is assigned the (R)-absolute configuration on the basis of its ORD curve.

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