Synthesis of Indazoles and Azaindazoles by Intramolecular Aerobic Oxidative C N Coupling under Transition??Metal??Free Conditions
J Hu, H Xu, P Nie, X Xie, Z Nie…
Index: Hu, Jiantao; Xu, Huacheng; Nie, Pengju; Xie, Xiaobo; Nie, Zongxiu; Rao, Yu Chemistry - A European Journal, 2014 , vol. 20, # 14 p. 3932 - 3938
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Abstract
Abstract A transition-metal-free oxidative C [BOND] N coupling method has been developed for the synthesis of 1H-azaindazoles and 1H-indazoles from easily accessible hydrazones. The procedure uses TEMPO, a basic additive, and dioxygen gas as the terminal oxidant. This reaction demonstrates better reactivity, functional group tolerance, and broader scope than comparable metal catalyzed reactions.
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