Palladium-catalysed synthesis of biaryl phosphines

C Baillie, J Xiao

Index: Baillie, Colin; Xiao, Jianliang Tetrahedron, 2004 , vol. 60, # 19 p. 4159 - 4168

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Citation Number: 53

Abstract

Monodentate, biphenyl-type phosphines have emerged as a powerful class of ligands in homogeneous catalysis. Synthetic methods for these ligands are limited, however. We report that the palladium-catalysed Suzuki coupling of OPR2 (o-C6H4X)(R= Ph, t-Bu; X= Br, I) with arylboronic acids affords a variety of biaryl phosphine oxides including those that contain heterocycles. The corresponding phosphines are readily obtained by treatment with ...